Immunoreactive insulin and C-peptide responses to oral administration of glucose were observed in seven cases of RH-787 intoxication. A comparative study was done between the RH-787 intoxication and the two gr ps of control and nonobese maturity onset diabetes, and the followings were the results of these studies.
I . Blood glucose changes following oral glucose loading:
1) Fasting blood glucose level in RH-787 intoxication group was 117.6+25.46 mg/100 ml (mean¡¾ S.E.), which was lower in value than that of diabetics.
2) The highest blood glucose concentration in. RH-787 intoxication group -was 269.7¡¾30.45 mg/ 100 ml at 60 minutes after glucose administration, while it was 299.8¡¾49.15 mg/100 ml at, 120 minutes in the diabetics, and 137.6¡¾4.83 mg/100 ml at 30 minutes in the control.
3) Blood glucose concentration at 180 minutes after glucose loading in RH-787 intoxication group was 186.9¡¾27.68 mg/100 ml, indicating glucose intolerance similar as in diabetics.
II. Circulating immunoreative insulin response to oral glucose loading:
1) Basal insulin level in RH-787 intoxication group was 22.1¡¾8.86 uU/ml, while it was 10.0¡¾2.29.uU/ ml in the diabetics and 19.2¡¾0.96 uU/ml in the control subjects.
2) Following stimulation by oral glucose loading in RH-787 intoxication group, insulin reached peak concentration" of 160.6-55.16 uU/ml at. 120 minutes after the onset of the stimulus, ¢¥-while in the group of diabetes the peak was 29.0+0.40 uU/mi at 120 minutes and in the control group it was 134.2¡¾35.33 uU/ml at 30 minutes.
I. C-peptide response to oral glucose loading:
1) Basal circulating C-peptide concentration in RH787 intoxication group was 0.82¡¾0.299ng/ml, while it was 1.83¡¾0.100 ng/ml in the control and 0.84¡¾ 0.437 ng/ml in the diabetics.
2) The highest concentration of C-peptide during glucose tolerance test in RH-787 intoxication was 5.15+1.421 ng/ml at 120 minutes, and 3.04¡¾0.881 ng/ml at 120 minutes in the diabetics.
From these results it can safely be concluded that RH-787-induced hyperglycemia may depend not so much. on the pancreatic dysfunction as on the extrapancreatic factors.
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